The sciatic nerve, the longest and widest single nerve in the human body, can become compressed or irritated for a variety of reasons, including a herniated disc, spinal stenosis, or muscle spasms in the piriformis muscle (a condition known as piriformis syndrome). So, what does a holistic approach to sciatic pain look like? It's a multi-faceted strategy that combines various therapies and lifestyle changes to reduce inflammation, improve mobility, and strengthen the body.